AN IMPROVED METHOD FOR THE DETECTION OF PEPTIDE-INDUCED UP-REGULATIONOF HLA-A2 MOLECULES ON TAP-DEFICIENT T2 CELLS

Authors
REGNER M CLAESSON MH BREGENHOLT S ROPKE M
Citation
M. Regner et al., AN IMPROVED METHOD FOR THE DETECTION OF PEPTIDE-INDUCED UP-REGULATIONOF HLA-A2 MOLECULES ON TAP-DEFICIENT T2 CELLS, Experimental and clinical immunogenetics, 13(1), 1996, pp. 30-35
Citations number
20
Categorie Soggetti
Genetics & Heredity",Immunology,Biology
Journal title
Experimental and clinical immunogenetics → ACNP
ISSN journal
02549670
Volume
13
Issue
1
Year of publication
1996
Pages
30 - 35
Database
ISI
SICI code
0254-9670(1996)13:1<30:AIMFTD>2.0.ZU;2-1
Abstract
Peptide-induced upregulation of MHC class I on TAP-deficient T2 cells is used to monitor peptide binding to class I molecules, We present a temperature-dependent modification of the T2 assay which increases the sensitivity of peptide binding to MHC class I with several orders of magnitude.