Mwm. Vandenbrekel et al., THE INCIDENCE OF MICROMETASTASES IN NECK DISSECTION SPECIMENS OBTAINED FROM ELECTIVE NECK DISSECTIONS, The Laryngoscope, 106(8), 1996, pp. 987-991
Although modern imaging techniques become more accurate for the assess
ment of lymph node metastases in the neck as criteria and technology e
volve, micrometastases remain occult with any technique. Even the rout
ine histopathological examination of neck dissection specimens is unab
le to detect all micrometastases. Because knowledge on the incidence o
f micrometastases in the clinically NO neck might be of importance for
decision making regarding elective treatment, a retrospective study o
n 96 elective neck dissections was conducted. Meticulous histopatholog
ical examination of the neck dissection specimens yielded 3092 lymph n
odes of which 67 (2.2%) were tumor-positive. Twenty-six of these 67 ly
mph node metastases were micrometastases. Of the 36 tumor-positive nec
k dissection specimens, 21 contained micrometastases. In 9 tumor-posit
ive specimens only micrometastases were found. This high incidence of
micrometastases has important implications for the diagnostic work-up,
the treatment, and histopathological examination of the NO neck.