Systemic inflammatory response syndrome is an early stage of the infec
tious process in humans and animals, which has not until now been well
recognized and defined, It is characterized by two or more of four we
ll-defined criteria and may develop into sepsis, severe sepsis or sept
ic shock, Past epidemiological investigations of sepsis and septic sho
ck did not provide enough comparable results and the early stage's of
infection were therefore neglected. A precise definition of the system
ic inflammatory response syndrome and the possibility of classifying a
ll the early stages of infection represents real progress in this area
, Further research on the systemic inflammatory response syndrome, on
a much larger scale, is now urgently needed.