Ir. Record et al., PROTECTION BY ZINC AGAINST UVA-INDUCED AND UVB-INDUCED CELLULAR AND GENOMIC DAMAGE IN-VIVO AND IN-VITRO, Biological trace element research, 53(1-3), 1996, pp. 19-25
For many years, zinc salts have been used both topically and orally to
treat minor burns and abrasions as well as to enhance wound repair in
man and animals. In this study we describe the protective effects of
zinc against UV-induced genotoxicity in vitro and against sunburn cell
formation in mouse skin in vivo. Cultured skin cells from neonatal mi
ce showed a dramatic increase in the number of micronuclei as a result
of UVA and UVB irradiation. Inclusion of zinc at 5 mu g/mL in the med
ium significantly reduced the frequency of micronuclei and of micronuc
leated cells. In hairless mice, topical application of zinc chloride f
or 5 consecutive days or a single application 2 h prior to UV exposure
reduced the number of sunburn cells in the epidermis as did applicati
on of zinc 1 h after exposure. Application 2 h after irradiation also
tended to have a protective effect, although there was a large variati
on between animals. It is proposed that an influx of zinc can protect
epidermal cells against some of the more delayed effects of UV-induced
damage.