THE CONTRIBUTION OF CYTOGENETICS TO THE HISTOGENESIS OF MENINGEAL HEMANGIOPERICYTOMA

Some controversy has existed regarding the nosology of meningeal heman giopericytoma. In the WHO's classification of 1979 these rumours were included as a subgroup of meningiomas, but for some authors, they shou ld not be classified as meningiomas. Cytogenetic studies on meningioma demonstrate monosomy or partial deletion of chromosome 22 in 60% of t hese tumors. There have been few cytogenetic studies about meningeal h emangiopericytoma. We present here the results of cytogenetic studies and fluorescence in situ hybridization in six cases of meningeal heman giopericytoma. In these rumours we have never found monosomy 22, but a ll six cases were hyperdiploid. These cytogenetic data might provide a dditional evidence to differenciate the meningeal hemangiopericytoma f rom the meningioma.