IMMUNOGENETIC FACTORS IN HPV-ASSOCIATED CERVICAL-CANCER - INFLUENCE ON DISEASE PROGRESSION

Authors
DUGGANKEEN MF KEATING PJ STEVENS FRA SINNOTT P SNIJDERS PJF WALBOOMERS JMM DAVIDSON S HUNTER RD DYER PA STERN PL
Citation
Mf. Duggankeen et al., IMMUNOGENETIC FACTORS IN HPV-ASSOCIATED CERVICAL-CANCER - INFLUENCE ON DISEASE PROGRESSION, European journal of immunogenetics, 23(4), 1996, pp. 275-284
Citations number
22
Journal title
European journal of immunogenetics → ACNP
ISSN journal
09607420
Volume
23
Issue
4
Year of publication
1996
Pages
275 - 284
Database
ISI
SICI code
0960-7420(1996)23:4<275:IFIHC->2.0.ZU;2-N
Abstract
No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west Englan d and controls (corrected P values). HLA-DRB11501/DQB1*0602 was non-s ignificantly increased, particularly among patients with HPV16-positiv e tumours. HLA-B7-positive patients had a significantly poorer clinica l outcome than HLA-B7-negative patients. A significant component of th e genotypic effect is down-regulation of HLA-B7 expression by the tumo ur cells.