Imaging studies can be helpful in identifying the etiology of conjugat
ed (direct) hyperbilirubinemia. An elevated direct bilirubin level sug
gests obstructive jaundice, and ultrasound or computed tomographic (CT
) imaging may identify the responsible structural lesion. Imaging can
also be used to guide percutaneous biopsy. A cost-effective strategy f
or determining the cause of direct hyperbilirubinemia rests on ultraso
und as the primary modality Endoscopic retrograde cholangiopancreatogr
aphy and CT are performed as follow-up studies only when necessary. Ma
gnetic resonance imaging is rarely useful.