NEURONAL LESIONS AND BEHAVIORAL-MODIFICATIONS IN RAT FOLLOWING CEREBRAL-ISCHEMIA AND REPERFUSION

Neurons of the mammalian CNS differ in their vulnerability to various disease processes and other insults, particularly in their response to total anoxia/ischemia. In this study we have tested the histological and behavioral modifications induced by experimental conditions of par tial cerebral ischemia in the rats, The specific morphological and his tological alterations, observed in our experimental conditions of reve rsible partial cerebral ischemia, confirm the selective vulnerability of certain neuronal populations to ischemic injury and are also eviden ced by behavioral modifications which may mirror the functional impair ment observed in humans after a transitory ischemic attack.