Objectives: The purpose of the present study was to correlate oral and
systemic symptoms of menopause and the oral health and salivary compo
sition and flow rate in a group of women in menopause prior to hormone
replacement therapy. Methods: One-hundred fifty-four women attending
a menopause clinic were divided into two groups. Group A,58 women, wit
hout any systemic disease or treatments, and Group B,96 women with dis
eases and on various medications. They answered a questionnaire on the
ir general health and oral and systemic complaints related to menopaus
e. Fifty-four of the women agreed to have an oral examination and sali
va analysis. Whole resting and submandibular (SM-SL) stimulated saliva
were analyzed. Results: The oral discomfort complaint was found in 45
% in Group A and in 60% in Group B. 74% complained of climacteric symp
toms in Group A and 63% in Group B. The odds ratio (OR) between oral d
iscomfort and climacterics complaints of menopause was 8.03 in Group A
and 4.08 in Group B. The salivary composition and flow rates did not
differ significantly between the groups of menopausal women. However t
he salivary total protein and IgA concentrations were significantly hi
gher in comparison to healthy young controls. Conclusions: The present
study reports a high prevalence of oral discomfort in the women atten
ding a menopause clinic. A highly significant odds ratio between syste
mic and oral complaints of menopause was found. The significantly alte
red salivary composition in these women might point to sympathetic act
ivation due to psychological stress.