EVALUATION OF HEMOSTASIS PARAMETERS BEFOR E AND AFTER DELIVERY IN PREGNANCIES WITH SIH AND PREECLAMPSIA COMPARED WITH NORMAL PREGNANCIES

Pregnancy is accompanished by a physiological activation of intravascu lar coagulation: however without disorder. Normal markers of coagulati on are unchanged despit activation. Special coagulation parameter - su ch as Thrombin-Antithrombin-III-complex (TAT) or D-Dimer are increased also in normal pregnant women. Pregnancy induced hypertension (SIH) a nd preeklampsia may be associated with a disorder of coagulation that preceedes the well known clinical manifestation of hypertension. There fore it was the aim of the study to distinguish both the pregnancy ind uced hypertension (15 patients) and preeklampsia (10 patients) as far as it is possible by coagulation parameters such as thrombin generatio n (by TAT), fibrinolysis (by D-Dimer), AT-III. platelets and others co mparing them with 25 normotensive pregnancies. In preeklampsia, the re sults showed that clinical signs were associated with simultaneous coa gulation abnormalities. TAT and D-Dimere are significant increased whe reas a decrease of AT-III and platelets was observed. There are no sig nificant differences between SIH and normal pregnancies. Three days al ter delivery there was an increase of D-Dimer, AT-III and platelets an d a decrease of TAT-complex in all groups. For risk pregnancy, the par ameters TAT and D-Dimer may be useful as screeningtest. They although may support confirming the diagnosis of preeklampsia.