CLINICAL AND LABORATORY MANIFESTATIONS OF HELLP-SYNDROME - A RETROSPECTIVE ANALYSIS

The HELLP-Syndrom (hemolysis, elevated liver enzymes, low platelet cou nt) is considered as a severe complication of eclampsia with unpredict able development of pregnancy including high maternal and fetal risk. The result of retrospective analysis of all deliveries of the years 19 86-1991 at the UFK Marburg were 28 cases of proved HELLP-Syndrom. Medi cal history, correlation of clinical and laboratory findings as well a s the development of the disease and the neonatal dates were evaluated by computerized documentation. The incidence of HELLP-Syndrom was 28 of 8111 deliveries at all (0,34%). 82% of the women with HELLP-Syndrom were primiparae. The leading symptom was right upper abdominal pain i n 75%, which lasted already 5,7 days before presentation in the clinic . Hypertonus, edema and proteinuria were present in 71%, 61% and 89% o f the cases. The diagnosis indicating laboratory finding was the throm bocytopenia (mean 62 G/l). In comparison to the thrombocytes. which we re at the 4.-7. day pp in 89% within the normal range, the liver funct ion tests normalized just between the 9. and 13. day pp (SGOT 89%, SGP T 77%). The shortening of the prepartal hospitalization from 6 days in 1986/87 to 8 hours in 1990/91 decreases the peri- and postnatal compl ication rate from 43% to 23%. 26/28 patients (92%) were delivered by c aesarean section from healthy babies through which were 75% premature infants and in 27% of the cases small for gestational age additionally . We conclude that the decrease of the diagnosis-delivery interval and the intensive medical care are responsible for the diminution of the maternal and neonatal mortality rate to 0%.