Despite much interest in HELLP syndrome in the last years, the aetiolo
gy of this unique form of severe preeclampsia is still unknown. We rep
ort the case of a young multipara with HELLP syndrome and Trisomy 18,
who had two uneventful pregnancies before and after the case reported
here. This case let us presume, that Trisomy 18, as described for Tris
omy 13, may be a risk factor for the development of a preeclampsia.