TOTAL SYNTHESIS OF CYCLOSTELLETTAMINE-C, A BISPYRIDINIUM MACROCYCLIC ALKALOID HAVING MUSCARINIC ACETYLCHOLINE-RECEPTOR ANTAGONISTIC ACTIVITY

Authors
ANAN H SEKI N NOSHIRO O HONDA K YASUMURO K OZASA T FUSETANI N
Citation
H. Anan et al., TOTAL SYNTHESIS OF CYCLOSTELLETTAMINE-C, A BISPYRIDINIUM MACROCYCLIC ALKALOID HAVING MUSCARINIC ACETYLCHOLINE-RECEPTOR ANTAGONISTIC ACTIVITY, Tetrahedron, 52(33), 1996, pp. 10849-10860
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
33
Year of publication
1996
Pages
10849 - 10860
Database
ISI
SICI code
0040-4020(1996)52:33<10849:TSOCAB>2.0.ZU;2-T
Abstract
Cyclostellettamine C (1), a bispyridinium macrocyclic compound having muscarinic acetylcholine receptor antagonistic activity, was synthesiz ed by the stepwise ring closure method via roxytridecyl)-1-[13-(3-pyri dyl)tridecyl]pyridinium trifluoromethanesulfonate (21). Through this s tudy, the structure of naturally originating 1 was synthetically and b iologically confirmed. Copyright (C) 1996 Published by Elsevier Scienc e Ltd