OPTIMIZATION OF FERMENTATION MEDIUM BY A MODIFIED METHOD OF GENETIC ALGORITHMS

Authors
ZUZEK M FRIEDRICH J CESTNIK B KARALIC A CIMERMAN A
Citation
M. Zuzek et al., OPTIMIZATION OF FERMENTATION MEDIUM BY A MODIFIED METHOD OF GENETIC ALGORITHMS, Biotechnology techniques, 10(12), 1996, pp. 991-996
Citations number
19
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology techniques → ACNP
ISSN journal
0951208X
Volume
10
Issue
12
Year of publication
1996
Pages
991 - 996
Database
ISI
SICI code
0951-208X(1996)10:12<991:OOFMBA>2.0.ZU;2-W
Abstract
During the study of mevinolin biosynthesis by Aspergillus terreus ATCC 20542, 10 different medium components were selected for medium optimi zation. A new optimization method based on genetic algorithms and indu ctive learning was used for experimental design. For better efficiency the method was supported by a model, constructed with machine learnin g method, to predict the productivity. In four generations of fermenta tion experiments the productivity increased nearly three times.