RNASE-E PROCESSING OF ESSENTIAL CELL-DIVISION GENES MESSENGER-RNA IN ESCHERICHIA-COLI

Citation
K. Cam et al., RNASE-E PROCESSING OF ESSENTIAL CELL-DIVISION GENES MESSENGER-RNA IN ESCHERICHIA-COLI, Nucleic acids research, 24(15), 1996, pp. 3065-3070
Citations number
30
Categorie Soggetti
Biology
Journal title
ISSN journal
03051048
Volume
24
Issue
15
Year of publication
1996
Pages
3065 - 3070
Database
ISI
SICI code
0305-1048(1996)24:15<3065:RPOECG>2.0.ZU;2-8
Abstract
The ratio of the FtsZ to FtsA proteins determines the correct initiati on of cell division in Escherichia coli. The genes for these proteins are contiguous on the chromosome. Although both genes are transcribed from common promoters, the presence of ftsZ-specific promoters, along with differences in the efficiency of translation of their respective mRNAs, contribute to the increased relative expression of ftsZ. We rep ort here that the polycistronic ftsA-ftsZ transcripts are cleaved by R Nase E and that this cleavage affects the decay of ftsA and ftsZ mRNA. As a consequence of the cleavage, RNase E also contributes to the dif ferential expression of the two genes.