HSP100 CLP PROTEINS - A COMMON MECHANISM EXPLAINS DIVERSE FUNCTIONS/

The HSP100/Clp proteins are a newly discovered family with a great div ersity of functions, such as increased tolerance to high temperatures, promotion of proteolysis of specific cellular substrates and regulati on of transcription. HSP100/Clp proteins are also synthesized in a var iety of specific patterns and, in eukaryotes, are localized to differe nt subcellular compartments. Recent data suggest that a common ability to disassemble higher-order protein structures and aggregates unifies the molecular functions of this diverse family.