ENZYMATIC RESOLUTION OF ALKYN-3-OLS IN NONAQUEOUS MEDIUM

Authors
SHARMA A SANKARANARAYANAN S CHATTOPADHYAY S
Citation
A. Sharma et al., ENZYMATIC RESOLUTION OF ALKYN-3-OLS IN NONAQUEOUS MEDIUM, Biotechnology letters, 18(12), 1996, pp. 1391-1394
Citations number
11
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
18
Issue
12
Year of publication
1996
Pages
1391 - 1394
Database
ISI
SICI code
0141-5492(1996)18:12<1391:EROAIN>2.0.ZU;2-W
Abstract
Resolution of alkyn-3-ols has been achieved using a lipase from Candid a rugosa to esterify the alcohols with trifluoroethyl butyrate in hexa ne to give the O-alcohols and the (R)-esters. Subsequent reacylation o f the product alcohols and alcoholysis of the esters with I-butanol fu rnished the O-alcohols with good (86-91% ees) and the (R)-butyrate wit h moderate enantiomeric purities (62-64% ees).