AN APPROACH TO THE SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING N-ACYLPHOSPHORAMIDATE INTERNUCLEOSIDIC LINKAGES

Authors
FILIPPOV D MEEUWENOORD NJ VANDERMAREL GA EFIMOV VA KUYLYEHESKIELY E VANBOOM JH
Citation
D. Filippov et al., AN APPROACH TO THE SOLID-PHASE SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING N-ACYLPHOSPHORAMIDATE INTERNUCLEOSIDIC LINKAGES, Synlett, (8), 1996, pp. 769
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
8
Year of publication
1996
Database
ISI
SICI code
0936-5214(1996):8<769:AATTSS>2.0.ZU;2-Z
Abstract
(2-Cyanoethoxy)(N,N-diisopropylamino) tyl)-beta-D-erythro-pentofuranur on-amido)phosphine 7 was used as a building unit in a stepwise solid p hase synthesis of an immobilized decamer employing 5-mercapto-1-methyl tetrazole as activation reagent. Decyanoethylation and release of the immobilized decamer from the support with methanolic potassium carbona te furnished modified oligonucleotide 16.