Wm. Sharman et al., NOVEL WATER-SOLUBLE PHTHALOCYANINES SUBSTITUTED WITH PHOSPHONATE MOIETIES ON THE BENZO RINGS, Tetrahedron letters, 37(33), 1996, pp. 5831-5834
The synthesis and characterization of a series of phthalocyanine deriv
atives bearing phosphonate substituents directly bound to the aromatic
rings of the phthalocyanine is described. These novel water-soluble p
hthalocyanine tetraphosphonates are of interest for different applicat
ions, particularly as photosensitizers in photodynamic therapy. Furthe
rmore, this synthetic approach allows for more versatility in the prep
aration of hydrophilic macrocycles. Copyright (C) 1996 Elsevier Scienc
e Ltd