2 EFFICIENT ROUTES FOR CONSTRUCTION OF AMIDINE-LINKED PSEUDO-DISACCHARIDE

Two routes for the synthesis of the amidine-linked pseudo-disaccharide were developed. The amidine linkage was constructed by the intermolec ular or intramolecular coupling between thioamide and amine in the pre sence of mercury (II) chloride. The former construction from D-arabino no-1,5-thiolactam and 6-amino-6-deoxy-D-glucoside gave the correspondi ng pseudo-disaccharide. The latter construction of the amidine linkage was demonstrated in the case of eoxy-D-thioarabinononyl)amino-4-deoxy -D-glucoside. Copyright (C) 1996 Elsevier Science Ltd