SILICON TETRACHLORIDE AND PHENOL AS N-ALPHA-T-BUTOXYCARBONYL GROUP DEPROTECTING AGENT IN SOLID-PHASE PEPTIDE-SYNTHESIS

Authors
SIVANANDAIAH KM BABU VVS GANGADHAR BP
Citation
Km. Sivanandaiah et al., SILICON TETRACHLORIDE AND PHENOL AS N-ALPHA-T-BUTOXYCARBONYL GROUP DEPROTECTING AGENT IN SOLID-PHASE PEPTIDE-SYNTHESIS, Tetrahedron letters, 37(33), 1996, pp. 5989-5990
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
33
Year of publication
1996
Pages
5989 - 5990
Database
ISI
SICI code
0040-4039(1996)37:33<5989:STAPAN>2.0.ZU;2-H
Abstract
The combination of 1M silicon tetrachloride and 3M phenol serves as an efficient N-alpha-t-butoxycarbonyl deblocking agent in solid phase pe ptide synthesis, the duration of the cleavage being 10 min. This is de monstrated by the synthesis of the naturally occurring mu-receptor sel ective opioid heptapeptide, dermorphin. Copyright (C) 1996 Elsevier Sc ience Ltd