POSTIRRADIATION LARYNGEAL OSTEOSARCOMA - CASE-REPORT AND LITERATURE-REVIEW

Background. Laryngeal sarcoma is a rare disease entity. In review of t he literature, chondrosarcoma is the most common sarcoma, followed by fibrosarcoma. Osteosarcoma is very rare; there are only seven cases re ported in the literature. Postirradiation sarcoma is a late complicati on of radiotherapy. Osteosarcoma is the most common type in this group . The larynx is often involved in the radiation field of treatment for head and neck malignancies. However, postirradiation laryngeal osteos arcoma has not yet been reported. Methods. We present a 56-year-old ma n who underwent radiotherapy for nasopharyngeal carcinoma 32 years ago and later developed a laryngeal osteosarcoma. Results. The patient un derwent total laryngectomy but died 1 year and 9 months later with loc ally extensive disease. Conclusions. We report the first case of posti rradiation laryngeal osteosarcoma. In addition to surgical treatment, adjunctive therapies should be considered for this group of patients. (C) 1997 John Wiley & Sons, Inc.