Purpose: Preliminary evaluations of the holmium:YAG laser have demonst
rated a variety of potential urological applications, including ablati
on of soft tissue lesions as well as stone fragmentation. We present o
ur experience with the holmium:YAG laser for intracorporeal lithotrips
y of urinary calculi. Materials and Methods: During a 24-month period
75 patients underwent 79 laser procedures, including retrograde ureter
oscopy for ureteral calculi (71) and fragmentation of caliceal stones
remote from the nephrostomy tract during percutaneous nephrolithotrips
y (8). Results: Complete stone fragmentation without need for addition
al procedures or lithotripsy was achieved in 85% of the cases. Treatme
nt failures included 1 case of stone migration, 7 incomplete fragmenta
tion requiring other lithotripsy devices and 3 laser malfunction. One
ureteral perforation occurred when the laser was activated without dir
ect visual guidance. Conclusions: The holmium:YAG laser has demonstrat
ed its efficacy as a method of intracorporeal lithotripsy. Advantages
include ability to fragment stones of all composition, and the multipu
rpose, multispecialty applications of the holmium wavelength. This las
er has potential soft tissue effects, and careful attention to techniq
ue during lithotripsy is required to avoid ureteral wall injury.