CONTROL OF ENZYME HYDRATION IN PENICILLIN AMIDASE CATALYZED SYNTHESISOF AMIDE BOND

Authors
EBERT C GARDOSSI L LINDA P
Citation
C. Ebert et al., CONTROL OF ENZYME HYDRATION IN PENICILLIN AMIDASE CATALYZED SYNTHESISOF AMIDE BOND, Tetrahedron letters, 37(52), 1996, pp. 9377-9380
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
52
Year of publication
1996
Pages
9377 - 9380
Database
ISI
SICI code
0040-4039(1996)37:52<9377:COEHIP>2.0.ZU;2-H
Abstract
Penicillin amidase catalyses the synthesis of amide bond in very high yield (>98%), using equimolar concentrations of the amine and the phen ylacetic components. In situ hydrated phosphates were employed for con trolling the water activity in a benzene/water system (97:3 v/v), wher e the water is taken up by the salt with formation of the hydrated spe cies. Copyright (C) 1996 Elsevier Science Ltd