CYTOTOXIC 8,9-SECOKAURANE DITERPENES FROM A NEW-ZEALAND LIVERWORT, LEPIDOLAENA-TAYLORII

Authors
PERRY NB BURGESS EJ TANGNEY RS
Citation
Nb. Perry et al., CYTOTOXIC 8,9-SECOKAURANE DITERPENES FROM A NEW-ZEALAND LIVERWORT, LEPIDOLAENA-TAYLORII, Tetrahedron letters, 37(52), 1996, pp. 9387-9390
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
52
Year of publication
1996
Pages
9387 - 9390
Database
ISI
SICI code
0040-4039(1996)37:52<9387:C8DFAN>2.0.ZU;2-9
Abstract
The main cytotoxic compound from the liverwort Lepidolaena taylorii is the known -8,9-seco-7-hydroxy-kaura-8(14),16-dien-9,15-dione 1. The r elative stereochemistry of a new cytotoxic compound, 16,17-dihydro der ivative 2, was supported by molecular modelling. Another new cytotoxic compound was identified as 8,14-epoxide 3 by preparation from 1. Thes e compounds showed differential cytotoxic activity against human tumor cell lines. Copyright (C) 1996 Elsevier Science Ltd