SUBCONJUNCTIVAL VERSUS INTRASCLERAL MITOMYCIN-C IN TRABECULECTOMY

BACKGROUND AND OBJECTIVE: A randomized prospective comparison of sub-T enon's administration of mitomycin-C (MMC) with intrascleral administr ation of MMC in trabeculectomy was performed to determine whether intr ascleral application is superior to the standard sub-Tenon's applicati on. PATIENTS AND METHODS: Twenty-four eyes of 23 patients were randomi zed to treatment with MMC (0.27 mg/ml for 5 minutes). The route of adm inistration was subconjunctival in group A and intrascleral in group B . Preoperative and postoperative visual acuity (VA), intraocular press ure (IOP), number of medications, and complications were compared betw een the two groups. RESULTS: There was no statistically significant di fference between the two groups preoperatively regarding VA, IOP, and number of medications. Postoperatively, IOP and number of medications required had decreased significantly in both groups. A significantly l arger number of postoperative procedures were required in group B to c ontrol IOP (group A = 3, group B = 14, P = .002). CONCLUSION: Both met hods of MMC application significantly decreased the IOP and the number of medicines required to control IOP after trabeculectomy. The intras cleral use of MMC resulted in the need for more surgery postoperativel y (P = .002).