BACKGROUND AND OBJECTIVE: A randomized prospective comparison of sub-T
enon's administration of mitomycin-C (MMC) with intrascleral administr
ation of MMC in trabeculectomy was performed to determine whether intr
ascleral application is superior to the standard sub-Tenon's applicati
on. PATIENTS AND METHODS: Twenty-four eyes of 23 patients were randomi
zed to treatment with MMC (0.27 mg/ml for 5 minutes). The route of adm
inistration was subconjunctival in group A and intrascleral in group B
. Preoperative and postoperative visual acuity (VA), intraocular press
ure (IOP), number of medications, and complications were compared betw
een the two groups. RESULTS: There was no statistically significant di
fference between the two groups preoperatively regarding VA, IOP, and
number of medications. Postoperatively, IOP and number of medications
required had decreased significantly in both groups. A significantly l
arger number of postoperative procedures were required in group B to c
ontrol IOP (group A = 3, group B = 14, P = .002). CONCLUSION: Both met
hods of MMC application significantly decreased the IOP and the number
of medicines required to control IOP after trabeculectomy. The intras
cleral use of MMC resulted in the need for more surgery postoperativel
y (P = .002).