CLONING OF CDNA-ENCODING HUMAN RAPSYN AND MAPPING OF THE RAPSN GENE LOCUS TO CHROMOSOME 11P11.2-P11.1

Authors
BUCKEL A BEESON D JAMES M VINCENT A
Citation
A. Buckel et al., CLONING OF CDNA-ENCODING HUMAN RAPSYN AND MAPPING OF THE RAPSN GENE LOCUS TO CHROMOSOME 11P11.2-P11.1, Genomics, 35(3), 1996, pp. 613-616
Citations number
12
Categorie Soggetti
Genetics & Heredity
Journal title
Genomics → ACNP
ISSN journal
08887543
Volume
35
Issue
3
Year of publication
1996
Pages
613 - 616
Database
ISI
SICI code
0888-7543(1996)35:3<613:COCHRA>2.0.ZU;2-D
Abstract
We have isolated and sequenced cDNA clones for the human 43-kDa acetyl choline receptor-associated protein rapsyn. The cDNA encodes a 412-ami no-acid protein that has a predicted molecular mass of 46,330 Da and s hows 96% sequence identity with mouse rapsyn. Analysis of PCR amplific ations, first from somatic cell hybrids and subsequently from radiatio n hybrids, localizes the human RAPSN gene locus to chromosome 11p11.2- p11.1 in close proximity to ACP2. (C) 1996 Academic Press, Inc.