SYNTHESIS, STRUCTURE AND CYTOTOXIC ACTIVITY OF PLATINUM(II) DIMERS WITH BRIDGING IMIDATE LIGANDS IN HEAD-TO-HEAD ARRANGEMENT

The cis-diammineplatinum(II) head-to-head dimer complexes with imidate ligands, [Pt-2(NH3)(4)(SI)(2)](NO3)(2) . H2O, [Pt-2(NH3)(4)(EMGI)(2)] (NO3)(2) and [Pt-2(NH3)(4)(DMGI)(2)](NO3)(2) (where SI = succinimidate , EMGI = 3-ethyl-3-methylglutarimidate and DMGI = 3,3-dimethylglutarim idate), are prepared from aqueous solutions of platinum(II) in the pre sence of the corresponding imides. These complexes form a pair of dime rs within the crystals stabilized by hydrogen bonds as shown by X-ray structural analysis. They exhibit high antitumor activities against S1 80 and L1210 cancer cell lines.