A. Spadaro et al., INTERLEUKIN-6 AND SOLUBLE INTERLEUKIN-2-RECEPTOR IN PSORIATIC-ARTHRITIS - CORRELATIONS WITH CLINICAL AND LABORATORY PARAMETERS, Clinical and experimental rheumatology, 14(4), 1996, pp. 413-416
Objective. In this study, we evaluated the relationships of IL-6 and s
IL-2R levels with the main clinical and laboratory parameters in PsA p
atients with peripheral polyarthritis. Methods. Serum levels of IL-6 a
nd sIL-2R were measured by an enzyme immunoassay kit in patients with
peripheral (< 4 joints) PsA (n=47), with RA (n=41), or with psoriasis
(n=15) and in healthy volunteers (n=15). Results. The patients with Ps
A had higher serum levels of IL-6 and sIL-2R than healthy volunteers a
nd psoriatic patients, while they showed lower levels of IL-6 and sIL-
2R than RA patients. We found abnormal values for IL-6 and sIL-2R in 6
3.8% and 57.4% of PsA patients, respectively. IL-6 levels correlated w
ith the number of painful and swollen joints, RAI, physician's assessm
ent, CRP and ESR, while sIL-2R levels correlated only with the number
of swollen joints, the physician's assessment and ESR. IL-6 and sIL-2R
correlated with each other. Conclusion. Our study shows that IL-6 and
sIL-2R may play a role in the pathogenetic mechanism of psoriatic art
hritis.