ACUTE ESTROGEN ADMINISTRATION CAN REVERSE COLD-INDUCED CORONARY RAYNAUDS-PHENOMENON IN SYSTEMIC-SCLEROSIS

Authors
LEKAKIS J MAVRIKAKIS M EMMANUEL M PRASSOPOULOS V PAPAMICHAEL C MOULOPOULOU D ZIAGA A KOSTAMIS P MOULOPOULOS S
Citation
J. Lekakis et al., ACUTE ESTROGEN ADMINISTRATION CAN REVERSE COLD-INDUCED CORONARY RAYNAUDS-PHENOMENON IN SYSTEMIC-SCLEROSIS, Clinical and experimental rheumatology, 14(4), 1996, pp. 421-424
Citations number
10
Categorie Soggetti
Rheumatology
Journal title
Clinical and experimental rheumatology → ACNP
ISSN journal
0392856X
Volume
14
Issue
4
Year of publication
1996
Pages
421 - 424
Database
ISI
SICI code
0392-856X(1996)14:4<421:AEACRC>2.0.ZU;2-J
Abstract
A 52-year-old postmenopausal woman with long-standing progressive syst emic sclerosis and Raynaud's phenomenon was examined by dipyridamole-t hallium-201 myocardial imaging and cold presser thallium-201 myocardia l scintigraphy. The dipyridamole test revealed normal myocardial perfu sion, while the cold pressor test showed reversible ischemia to the an teroapical myocardial wall, indicating coronary Raynaud's phenomenon. Acute intravenous administration of conjugated estrogens led to normal ization of the cold-induced thallium-201 defect. This is the first rep orted case of the beneficial effect of estrogens in coronary Raynaud's phenomenon.