SOLID-PHASES OF DELAVIRDINE MESYLATE

Delavirdine mesylate was recrystallized from solution under a variety of conditions. Seven crystal forms and a stable amorphous phase were i solated from solution. Two of these crystal forms were polymorphic anh ydrates: form XI (U-90152T) and form VIII (U-90152S). Two hydrates (fo rms VI and XIV), an ethanol solvate (form VII), an acetonitrile solvat e (form XIII), and a solvate from methanol/acetone (form XII) were als o identified. Six additional phases were identified as the products of solid-state transformations of the hydrated and solvated phases. The solid phases were differentiated by infrared spectroscopy and X-ray po wder diffraction. Several of the solid-state phase transformations wer e mediated by atmospheric moisture. These transformations were studied as a function of relative humidity with dynamic moisture sorption gra vimetry (DMSG). DMSG also provided useful measurements of hygroscopici ty.