COMPLEX TRANSLOCATION(7-22) IDENTIFIED IN AN EPITHELIOID HEMANGIOENDOTHELIOMA

We describe a malignant epithelioid hemangioendothelioma arising in th e back of a 45-year-old man with pulmonary and bone marrow metastases. Light microscopic and immunohistochemical features of this tumor are presented. Karyotyping revealed several clonal abnormalities: a comple x unbalanced translocation (7;22) involving multiple breakpoints (conf irmed by fluorescence in situ hybridization), a Robertsonian t(14;14), and loss of the Y chromosome. Monosomy for chromosome 11 was noted in a subset of the tumor cells. To our knowledge a karyotype has not bee n previously reported for this unusual vascular tumor. (C) Elsevier Sc ience Inc., 1996