LENNOX-GASTAUT SYNDROME-ASSOCIATED WITH LEUKOENCEPHALOPATHY

We report a 13-year-old boy with Lennox-Gastaut syndrome (LGS) associa ted with leukoencephalopathy, He was diagnosed with unclassified acute lymphocytic leukemia at the age of 3 years. After initial chemotherap y, he received intravenous methotrexate (total dosage 1,035 mg), intra thecal methotrexate (total dosage 221 mg), and whole brain irradiation (2,400 cGy), From about the age of 8 years, he developed slurred spee ch, hyperactivity, and mental deterioration, Cranial CT revealed calci fication of the subcortical white matter, At age 9 years, he exhibited tonic seizures and atonic seizures, EEG showed diffuse slow spike-wav e discharges, which are characteristic of LGS, Although multiple antie pileptic drugs have been prescribed, the frequency of seizures remains unchanged and his mental state is becoming progressively worse.