SYNTHESIS AND RECEPTOR-BINDING AFFINITY OF CHOLECYSTOKININ RECEPTOR LIGANDS - 2-INDOLYL AND 1-INDOLYL DERIVATIVES OF PD134308

Authors
ARALDI G DONATI D OLIOSI B URSINI A VANAMSTERDAM F NATALINI B PELLICCIARI R TARZIA G
Citation
G. Araldi et al., SYNTHESIS AND RECEPTOR-BINDING AFFINITY OF CHOLECYSTOKININ RECEPTOR LIGANDS - 2-INDOLYL AND 1-INDOLYL DERIVATIVES OF PD134308, Il Farmaco, 51(7), 1996, pp. 471-476
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
51
Issue
7
Year of publication
1996
Pages
471 - 476
Database
ISI
SICI code
0014-827X(1996)51:7<471:SARAOC>2.0.ZU;2-Q
Abstract
The synthesis of two ''dipeptoids'' structurally related to the CCK-B antagonist CI-988 (PD134308)(1-2) is described. The 2-and 1-indolyl de rivatives 4a,b were prepared in order to define the role of the trypto phan moiety in this series of ''dipeptoids''. They were evaluated as c ompetitors in the binding of [H-3]-CCK8s on guinea pig brain CCK-B rec eptors.