RENAL PHOSPHOLIPID-METABOLISM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

The effect of acute and chronic streptozotocin-induced diabetes on pho spholipid metabolism in papillary, medullary and cortical slices was s tudied. No changes were observed in either the phospholipid content or composition in the papilla, medulla and cortex from acute and chronic diabetic rats. With reference to (U-C-14)glycerol incorporation in th e papilla from chronic diabetic rats, it increased in PtdCho, PtdIns a nd PtdEtn. In the medulla, the incorporation to PtdCho decreased in th e acute diabetic state, while in the chronic diabetic state the incorp oration to PtdCho and PtdIns decreased. No changes were observed in co rtical phospholipids from diabetic rats. As regards P-32-sodium orthop hosphate incorporation to phospholipids, while it increased in PtdCho, PtdIns and PtdEtn in the papilla from acute and chronic diabetic rats , in the medulla from both groups, the incorporation in PtdCho and Ptd Ins decreased, and in the cortex from acute diabetic rats it decreased only in PtdIns. Even though no changes were detected in phospholipid composition, alterations in phospholipid metabolism were induced by ex perimental diabetes.