PROPHYLACTIC EFFECT OF SEROTONIN UPTAKE INHIBITORS AGAINST MOTION SICKNESS IN SUNCUS-MURINUS

Authors
OKADA F SAITO H MATSUKI N
Citation
F. Okada et al., PROPHYLACTIC EFFECT OF SEROTONIN UPTAKE INHIBITORS AGAINST MOTION SICKNESS IN SUNCUS-MURINUS, European journal of pharmacology, 309(1), 1996, pp. 33-35
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
309
Issue
1
Year of publication
1996
Pages
33 - 35
Database
ISI
SICI code
0014-2999(1996)309:1<33:PEOSUI>2.0.ZU;2-2
Abstract
The prophylactic effect of serotonin uptake inhibitors, imipramine and fluoxetine, against motion sickness was investigated in Suncus murinu s. Imipramine (s.c.) and fluoxetine (i.p.) inhibited motion-induced em esis dose dependently with ID50 values of 1.7 and 26 mg/kg, respective ly. The results suggest that increasing the concentration of serotonin in the synaptic cleft can prevent motion induced emesis and that sero tonin uptake inhibitors are effective as anti-motion sickness drugs.