LIVEDO-RETICULARIS AND THROMBOTIC PURPURA RELATED TO THE USE OF DIPHENHYDRAMINE ASSOCIATED WITH PYRITHYLDIONE

Citation
A. Morell et al., LIVEDO-RETICULARIS AND THROMBOTIC PURPURA RELATED TO THE USE OF DIPHENHYDRAMINE ASSOCIATED WITH PYRITHYLDIONE, Dermatology, 193(1), 1996, pp. 50-51
Citations number
8
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
ISSN journal
10188665
Volume
193
Issue
1
Year of publication
1996
Pages
50 - 51
Database
ISI
SICI code
1018-8665(1996)193:1<50:LATPRT>2.0.ZU;2-Q
Abstract
We describe the case of a young woman who habitually took large doses of a combination of diphenhydramine and pyrithyldione. She complained of arthralgia, painful recurring plaques and nodules, together with pe rsistent reticular purpuric mottling and areas of necrosis on her legs . There were positive antinuclear antibodies and rheumatoid factor and histologically massive thrombosis of the dermal vessels without signs of vasculitis. Other cases of similar adverse reactions attributed to this drug combination used as a hypnotic have been described.