A. Morell et al., LIVEDO-RETICULARIS AND THROMBOTIC PURPURA RELATED TO THE USE OF DIPHENHYDRAMINE ASSOCIATED WITH PYRITHYLDIONE, Dermatology, 193(1), 1996, pp. 50-51
We describe the case of a young woman who habitually took large doses
of a combination of diphenhydramine and pyrithyldione. She complained
of arthralgia, painful recurring plaques and nodules, together with pe
rsistent reticular purpuric mottling and areas of necrosis on her legs
. There were positive antinuclear antibodies and rheumatoid factor and
histologically massive thrombosis of the dermal vessels without signs
of vasculitis. Other cases of similar adverse reactions attributed to
this drug combination used as a hypnotic have been described.