ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS INDUCED BY DEXAMETHASONE INJECTION

A 52-year-old woman, without a history of psoriasis, developed a wides pread, sterile pustular eruption on the trunk and extremities 2 days a fter subcutaneous injection of dexamethasone solution. Skin biopsy rev ealed subcorneal pustules filled with neutrophils and moderate lymphoh istiocytic infiltrate with a few eosinophils in the dermis, There was no evidence of vasculitis. Patch testing showed positive pustular reac tions to dexamethasone solution. Histology of this pustule also resemb led that of the original eruption. To our knowledge, acute generalized exanthematous pustulosis due to corticosteroid has not been previousl y reported.