Salmonella infection can cause appendicitis by direct invasion of the
appendix, or can mimic appendicitis by causing mild inflammation of th
e appendix, ileum, or lymph nodes. Clinical presentation and radiologi
c and laboratory evaluation may not distinguish the extent of underlyi
ng pathology. This case of a child with an atypical presentation of Sa
lmonella who underwent diagnostic laparotomy illustrates the overlap o
f enteric infections and acute appendicitis. A literature review confi
rms the variety of clinical scenarios of patients with suspected appen
dicitis and Salmonella-positive cultures. We conclude that enteric inf
ection should be considered in children with atypical presentations of
appendicitis, and that the knowledge that Salmonella can progress to
appendicitis should guide management if signs and symptoms of appendic
itis develop.