OXIDATIVE POSTTRANSLATIONAL MODIFICATIONS IN ALZHEIMER-DISEASE - A POSSIBLE PATHOGENIC ROLE IN THE FORMATION OF SENILE PLAQUES AND NEUROFIBRILLARY TANGLES

Authors
SMITH MA SAYRE LM MONNIER VM FERRY G
Citation
Ma. Smith et al., OXIDATIVE POSTTRANSLATIONAL MODIFICATIONS IN ALZHEIMER-DISEASE - A POSSIBLE PATHOGENIC ROLE IN THE FORMATION OF SENILE PLAQUES AND NEUROFIBRILLARY TANGLES, Molecular and chemical neuropathology, 28(1-3), 1996, pp. 41-48
Citations number
41
Categorie Soggetti
Pathology,Neurosciences
Journal title
Molecular and chemical neuropathology → ACNP
ISSN journal
10447393
Volume
28
Issue
1-3
Year of publication
1996
Pages
41 - 48
Database
ISI
SICI code
1044-7393(1996)28:1-3<41:OPMIA->2.0.ZU;2-T
Abstract
The distinctive pathological lesions of Alzheimer disease (AD), senile plaques, and neurofibrillary tangles comprise aggregates of insoluble fibrillar protein. We and other investigators recently demonstrated t hat several mechanisms related to oxidative stress and free-radical re actions could play a crucial role in the pathogenesis of AD and, speci fically, in the formation of senile plaques and neurofibrillary tangle s (NFT).