TRANSITION-METAL SACCHARIDE CHEMISTRY AND BIOLOGY - SYNTHESIS, CHARACTERIZATION, ELECTROCHEMISTRY AND EPR STUDIES OF OXOVANADIUM(IV) COMPLEXES OF SACCHARIDES AND THEIR DERIVATIVES AND IN-VITRO INTERACTION OF SOME OF THESE WITH RIBONUCLEASE AND DEOXYRIBONUCLEASE
A. Sreedhara et al., TRANSITION-METAL SACCHARIDE CHEMISTRY AND BIOLOGY - SYNTHESIS, CHARACTERIZATION, ELECTROCHEMISTRY AND EPR STUDIES OF OXOVANADIUM(IV) COMPLEXES OF SACCHARIDES AND THEIR DERIVATIVES AND IN-VITRO INTERACTION OF SOME OF THESE WITH RIBONUCLEASE AND DEOXYRIBONUCLEASE, Carbohydrate research, 289, 1996, pp. 39-53
Low molecular weight, water-soluble saccharide complexes of oxovanadiu
m(IV) have been synthesized and characterized by analytical, spectrosc
opic and electrochemical techniques. All the complexes were found to b
e mononuclear, possessing the VO2+ moiety, These are shown to be hydro
lytically and oxidatively stable over a wide range of pH (1-12) and ha
ve been extensively characterized by absorption and EPR spectroscopy a
nd by electrochemistry, Several correlations have been drawn from the
data generated. Some of these complexes have been demonstrated to poss
ess in vitro RNase inhibition activity with no effect on DNase. This s
uggests that these molecules closely mimic the substrate portion of th
e RNase-catalysed RNA hydrolysis and can act as transition-state analo
gues to RNase. (C) 1996 Elsevier Science Ltd.