WEDGE RESECTION TO IMPROVE INSULIN-RESISTANCE IN POLYCYSTIC-OVARY-SYNDROME - A STUDY AMONG CHINESE WOMEN

Objective To investigate the relation between androgen excess and insu lin resistance in nonobese Chinese women with polycystic ovary syndrom e. Design A prospective, controlled study. Setting School of Clinical Medicine, Nanjing University. Subjects There were three groups: Group I (n = 15) comprised nonobese women with polycystic ovary syndrome; Gr oup 2 comprised 12 of these 15 women in whom bilateral wedge resection had been performed six months to one year before enrolling in the stu dy. Group 3 was a control group comprised of 15 normally menstruating women of similar age and body mass index. Methods An oral glucose (100 g) tolerance test was performed in all women in each group. The areas under the response curve of serum glucose, insulin, C-peptide (C-P), insulin/glucose (I/G) and C-P/insulin (C/I) were calculated by trapezo id rule. Results When fasting the three groups had similar levels of g lucose, insulin, C-P, I/G and C/I. During the oral glucose tolerance t est women of Group 1 had a significantly higher mean serum area of the curve of glucose, insulin, C-P and I/G levels and lower C/I values, c ompared with the other two groups. Women of Group 2 and those in the c ontrol group showed similar levels of these indices during the oral gl ucose tolerance test. Conclusions Androgen excess in women with polycy stic ovary syndrome may be responsible for a defect in peripheral insu lin sensitivity and hepatic extraction which could be reversed by remo ving excessive androgens with wedge resection.