SYNTHESIS AND TC-99M LABELING OF CYCLIC GP IIB IIIA RECEPTOR ANTAGONISTS CONJUGATED TO 4,5-BIS(MERCAPTOACETAMIDO)-PENTANOIC ACID (MAPT)/

Authors
RAJOPADHYE M EDWARDS DS BOURQUE JP CARROLL TR
Citation
M. Rajopadhye et al., SYNTHESIS AND TC-99M LABELING OF CYCLIC GP IIB IIIA RECEPTOR ANTAGONISTS CONJUGATED TO 4,5-BIS(MERCAPTOACETAMIDO)-PENTANOIC ACID (MAPT)/, Bioorganic & medicinal chemistry letters, 6(15), 1996, pp. 1737-1740
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
15
Year of publication
1996
Pages
1737 - 1740
Database
ISI
SICI code
0960-894X(1996)6:15<1737:SATLOC>2.0.ZU;2-4
Abstract
The synthesis of cyclic Arg-Gly-Asp GP Ilb/IIIa receptor antagonists c onjugated to ,5-bis(S-1-ethoxyethyl-mercaptoacetamido)pentanoic acid i s reported. The corresponding Tc-99m-labeled complexes were prepared b y exchange labeling with Tc-99m-glucoheptonate. This indirect labeling approach is an alternative to the preformed chelate approach using ma pt. Copyright (C) 1996 The DuPont Merck Pharmaceutical Company.