TC-99M-LABELED FIBRINOGEN RECEPTOR ANTAGONISTS - DESIGN AND SYNTHESISOF CYCLIC RGD PEPTIDES FOR THE DETECTION OF THROMBI

Authors
HARRIS TD RAJOPADHYE M DAMPHOUSSE PR GLOWACKA D YU KM BOURQUE JP BARRETT JA DAMPHOUSSE DJ HEMINWAY SJ LAZEWATSKY J MAZAIKA T CARROLL TR
Citation
Td. Harris et al., TC-99M-LABELED FIBRINOGEN RECEPTOR ANTAGONISTS - DESIGN AND SYNTHESISOF CYCLIC RGD PEPTIDES FOR THE DETECTION OF THROMBI, Bioorganic & medicinal chemistry letters, 6(15), 1996, pp. 1741-1746
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
15
Year of publication
1996
Pages
1741 - 1746
Database
ISI
SICI code
0960-894X(1996)6:15<1741:TFRA-D>2.0.ZU;2-B
Abstract
Tc-99m labeled derivatives of N-Me-Arg-Gly-Asp containing cyclic pepti de GP IIb/IIIa receptor antagonists are potential radiopharmaceuticals for the diagnosis of thrombosis. The design and synthesis of these pe ptides are described. These compounds are incorporated in rapidly grow ing thrombi under both arterial and venous conditions in canine models . Thrombi are clearly visible in images acquired at 50 min. Copyright (C) 1996 The DuPont Merck Pharmaceutical Company.