POTENT AND SELECTIVE PKC INHIBITORY 5-MEMBERED RING ANALOGS OF BALANOL WITH REPLACEMENT OF THE CARBOXAMIDE MOIETY

Authors
JAGDMANN GE DEFAUW JM LAMPE JW DARGES JW KALTER K
Citation
Ge. Jagdmann et al., POTENT AND SELECTIVE PKC INHIBITORY 5-MEMBERED RING ANALOGS OF BALANOL WITH REPLACEMENT OF THE CARBOXAMIDE MOIETY, Bioorganic & medicinal chemistry letters, 6(15), 1996, pp. 1759-1764
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
15
Year of publication
1996
Pages
1759 - 1764
Database
ISI
SICI code
0960-894X(1996)6:15<1759:PASPI5>2.0.ZU;2-F
Abstract
Balanol ((-)-1) is a potent protein kinase inhibitory natural product isolated from the fungus Verticillium balanoides. The lack of cellular activity and protein kinase C selectivity in balanol has prompted a s earch for analogs that incorporate these properties, This paper descri bes the synthesis and biological activity of such compounds with subst itution similar to balanol, but with a single atom bridge in place of the carboxamide moiety. Copyright (C) 1996 Elsevier Science Ltd