SYNTHESIS OF FURO[2,3-C]PYRAN-BETA-D-THYMIDINE

Authors
BOUSQUIE I MADIOT V FLORENT JC MONNERET C
Citation
I. Bousquie et al., SYNTHESIS OF FURO[2,3-C]PYRAN-BETA-D-THYMIDINE, Bioorganic & medicinal chemistry letters, 6(15), 1996, pp. 1815-1818
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
15
Year of publication
1996
Pages
1815 - 1818
Database
ISI
SICI code
0960-894X(1996)6:15<1815:SOF>2.0.ZU;2-8
Abstract
A furo[2,2-c]pyran-beta-D-thymidine nucleoside analog was synthesized from 5'-O-TBDMS-3'-C-allyl-thymidine by 4'-C-hydroxymethylation follow ed by an electrophilic 6-membered ring annellation. The new bicyclonuc leoside was devoid of activity against HIV. Copyright (C) 1996 Elsevie r Science Ltd