SILDENAFIL (VIAGRA(TM)), A POTENT AND SELECTIVE INHIBITOR OF TYPE-5 CGMP PHOSPHODIESTERASE WITH UTILITY FOR THE TREATMENT OF MALE ERECTILE DYSFUNCTION

Authors
TERRETT NK BELL AS BROWN D ELLIS P
Citation
Nk. Terrett et al., SILDENAFIL (VIAGRA(TM)), A POTENT AND SELECTIVE INHIBITOR OF TYPE-5 CGMP PHOSPHODIESTERASE WITH UTILITY FOR THE TREATMENT OF MALE ERECTILE DYSFUNCTION, Bioorganic & medicinal chemistry letters, 6(15), 1996, pp. 1819-1824
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
15
Year of publication
1996
Pages
1819 - 1824
Database
ISI
SICI code
0960-894X(1996)6:15<1819:S(APAS>2.0.ZU;2-D
Abstract
-(2'-Alkoxyphenyl)pyrazolo[4,3-d]pyrimidin-7-ones, and in particular o ur preferred compound, sildenafil (VIAGRA(TM)), discovered through a r ational drug design programme, are potent and selective inhibitors of the type 5 cGMP phosphodiesterase from both rabbit platelets and human corpus cavernosum. Sildenafil is currently in the clinic for the oral treatment of male erectile dysfunction. Copyright (C) 1996 Elsevier S cience Ltd