IDENTIFICATION AND CHARACTERIZATION OF AN INHIBITOR OF INTERLEUKIN-8 - A RECEPTOR-BASED APPROACH

Authors
ATTWOOD MR BORKAKOTI N BOTTOMLEY GA CONWAY EA COWAN I FALLOWFIELD AG HANDA BK JONES PS KEECH E KIRTLAND SJ WILLIAMS G WILSON FX
Citation
Mr. Attwood et al., IDENTIFICATION AND CHARACTERIZATION OF AN INHIBITOR OF INTERLEUKIN-8 - A RECEPTOR-BASED APPROACH, Bioorganic & medicinal chemistry letters, 6(15), 1996, pp. 1869-1874
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
15
Year of publication
1996
Pages
1869 - 1874
Database
ISI
SICI code
0960-894X(1996)6:15<1869:IACOAI>2.0.ZU;2-6
Abstract
Identification of the extracellular domains of the interleukin-8 (IL-8 ) receptor led to the synthesis of several peptide sequences. A peptid e derived from a single subdomain was shown to inhibit IL-8 binding an d to act as a functional antagonist. Ala-scan and truncation strategie s identified key areas of this peptide for further work. Copyright (C) 1996 Elsevier Science Ltd