Osteosarcomas arising in irradiated tissues are uncommon but important
complications of radiotherapy. Radiation-induced osteosarcomas genera
lly occur 3-30 years after exposure and are most common after radiothe
rapy for cervical or breast carcinoma. These tumors are usually rapidl
y growing, extremely painful, and histologically high grade. In this p
aper, we report two cases of high-grade post-radiation osteosarcoma of
the scapula. Despite being almost identical radiologically and pathol
ogically, one case had a typical clinical presentation whereas the sec
ond case had two unusual features. being non-painful and arising in a
field initially irradiated for bronchogenic carcinoma.