N. Ahmad et al., METAL-INDEPENDENT PUTATIVE SUPEROXIDE-DISMUTASE MIMICS IN CHEMISTRY, BIOLOGY, AND MEDICINE, Ecotoxicology and environmental safety, 34(2), 1996, pp. 141-144
The excessive generation of superoxide radicals O-2 with inadequate av
ailable defence provided by the enzyme superoxide dismutase (SOD) may
result in the development and exacerbation of many of mankind's common
illnesses. The native SOD proves too problematic to be used for the p
revention and cure of such diseases. A number of metal-independent syn
thetic SOD mimics, based on organic nitroxides, have been tried as the
rapeutic interventions. Among the widely studied mimics, 2-ethyl-2,5,5
-trimethyl-3-oxazolidinanyl, 2,2,6,6-tetramethyl-1-piperidimyloxy, nit
rosoureas, and triazene derivatives have indicated promising results w
ith possible future applications in chemistry, biology, and medicine.
(C) 1996 Academic Press, Inc.